Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance

N Shunmoogam, P Naidoo… - Vascular health and risk …, 2018 - Taylor & Francis
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated
to play a role in several human diseases including diabetes mellitus and atherosclerosis …

Paraoxonase-1 activity in patients with cancer: A systematic review and meta-analysis

M Arenas, E Rodríguez, A Sahebkar, S Sabater… - Critical reviews in …, 2018 - Elsevier
Abstract Purpose Paraoxonase-1 (PON1) is a lipolactonase implicated in the elimination of
carcinogenic free radicals and in the scavenging mechanisms to maintain oxidative balance …

Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

DV Zhernakova, TH Le, A Kurilshikov, B Atanasovska… - Nature …, 2018 - nature.com
Despite a growing body of evidence, the role of the gut microbiome in cardiovascular
diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide …

[HTML][HTML] The role of acetylcholinesterase, paraoxonase, and oxidative stress in breast tumors

P Paydar, G Asadikaram, HZ Nejad… - International journal of …, 2018 - brieflands.com
Background: Oxidative stress is associated with the development of a large variety of
malignancies. Objectives: This study was conducted to evaluate the acetylcholinesterase …

A case‐control study: the association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus

JA Crow, EC Meek, RW Wills… - … Research and Reviews, 2018 - Wiley Online Library
Background A longitudinal study assessed serum paraoxonase 1 (PON1) activity and
concentration as affected by age and as associated with the development of type 2 diabetes …

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes

A Mahrooz, MB Hashemi-Soteh, M Heydari… - Clinica Chimica …, 2018 - Elsevier
Objective Genome studies have shown that the genes encoding paraoxonase 1 (PON1) and
PON2 are associated with glucose metabolism. The goal of this study was to simultaneously …

Quercetin ameliorates chlorpyrifos‐induced oxidative stress in the rat brain: Possible involvment of PON2 pathway

S Ghahremani, M Soodi, A Atashi - Journal of food biochemistry, 2018 - Wiley Online Library
In the present study, protective effect of quercetin against chlorpyrifos‐induced oxidative
stress in the brain of rat and possible involvement of paraoxanase2 (PON2) pathway was …

Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

S Broadgate, C Kiire, S Halford… - Acta Ophthalmologica, 2018 - Wiley Online Library
Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease
and is one of the leading causes of blindness in adults worldwide. It can be divided into …

PON1 L55M and Q192R gene polymorphisms and CAD risks in patients with hyperlipidemia

H Chen, S Ding, M Zhou, X Wu, X Liu, J Liu, Y Wu… - Herz, 2018 - search.proquest.com
Objective A decreased plasma high density lipoprotein (HDL) cholesterol level is a strong
risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the …

Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case–control studies

D Liao, H Yu, L Han, C Zhong, X Ran, D Wang… - Journal of …, 2018 - Springer
Purpose Evidences showed that paraoxonase 1 (PON1) gene polymorphism has an impact
on women's susceptibility to polycystic ovarian syndrome (PCOS) by influencing the …