Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is
clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and …

Objective To examine neurofilament (Nf) concentrations according to symptom onset and
clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). Methods We …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

The changing landscape of motor neuron disease imaging: the... : Current Opinion in
Neurology The changing landscape of motor neuron disease imaging: the transition from …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …

Objective To investigate the relationship of in vivo microglial activation to clinical and MRI
parameters in MS. Methods Patients with secondary progressive MS (n= 10) or relapsing …

Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the
corticomotorneuronal network responsible for voluntary movement. There are well …