Combinational strategy for high-performance cancer chemotherapy
SY Qin, YJ Cheng, Q Lei, AQ Zhang, XZ Zhang - Biomaterials, 2018 - Elsevier
The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from
satisfactory due to some issues such as tumor heterogeneity and resistance to …
satisfactory due to some issues such as tumor heterogeneity and resistance to …
Translatable high drug loading drug delivery systems based on biocompatible polymer nanocarriers
Most nanocarriers possess low drug loading, resulting in frequently repeated administration
and thereby high cost and increased side effects. Furthermore, the characteristics of …
and thereby high cost and increased side effects. Furthermore, the characteristics of …
High drug loading and sub-quantitative loading efficiency of polymeric micelles driven by donor–receptor coordination interactions
Polymeric micelles are extensively used for the delivery of hydrophobic drugs, which,
however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability …
however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability …
Polymeric nanoparticles with a glutathione‐sensitive heterodimeric multifunctional prodrug for in vivo drug monitoring and synergistic cancer therapy
Polymeric micelle‐based drug delivery systems have dramatically improved the delivery of
small molecular drugs, yet multiple challenges remain to be overcome. A polymeric …
small molecular drugs, yet multiple challenges remain to be overcome. A polymeric …
[HTML][HTML] Hypoxia-responsive lipid-poly-(hypoxic radiosensitized polyprodrug) nanoparticles for glioma chemo-and radiotherapy
L Hua, Z Wang, L Zhao, H Mao, G Wang, K Zhang… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Treatment of malignant glioma is a challenge facing cancer therapy. In addition to
surgery, and chemotherapy, radiotherapy (RT) is one of the most effective modalities of …
surgery, and chemotherapy, radiotherapy (RT) is one of the most effective modalities of …
Co‐delivery of drugs and genes using polymeric nanoparticles for synergistic cancer therapeutic effects
Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have
been widely studied for cancer treatment in the past decade. To achieve an efficient and …
been widely studied for cancer treatment in the past decade. To achieve an efficient and …
Smart self-assembled nanosystem based on water-soluble pillararene and rare-earth-doped upconversion nanoparticles for ph-responsive drug delivery
Exploring novel drug delivery systems with good stability and new structure to integrate
pillararene and upconversion nanoparticles (UCNPs) into one system continues to be an …
pillararene and upconversion nanoparticles (UCNPs) into one system continues to be an …
Ultrasound-targeted photodynamic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbubbles loaded with …
Triple-negative breast cancer (TNBC), which is a kind of aggressive breast cancer, has a
much higher recurrence rate and a shorter overall survival rate than other breast cancer …
much higher recurrence rate and a shorter overall survival rate than other breast cancer …
Positively charged polyprodrug amphiphiles with enhanced drug loading and reactive oxygen species-responsive release ability for traceable synergistic therapy
Y Li, Y Li, W Ji, Z Lu, L Liu, Y Shi, G Ma… - Journal of the American …, 2018 - ACS Publications
Due to the vast differences in chemical properties among small molecule drugs, nucleotide
drugs, and superparamagnetic iron oxide nanocubes (SPIONs), such as charge and …
drugs, and superparamagnetic iron oxide nanocubes (SPIONs), such as charge and …
pH-and enzyme-sensitive IR820–paclitaxel conjugate self-assembled nanovehicles for near-infrared fluorescence imaging-guided chemo–photothermal therapy
D Zhang, J Zhang, Q Li, H Tian, N Zhang… - … applied materials & …, 2018 - ACS Publications
The short lifetime and easy quick elimination of the near-infrared (NIR) dye new indocyanine
green (IR820) in the body restrict its practical application as a photothermal agent in cancer …
green (IR820) in the body restrict its practical application as a photothermal agent in cancer …