Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus

E Ríos - Journal of General Physiology, 2018 - rupress.org
Ryanodine-sensitive intracellular Ca2+ channels (RyRs) open upon binding Ca2+ at
cytosolic-facing sites. This results in concerted, self-reinforcing opening of RyRs clustered in …

Measurement of force and calcium release using mechanically skinned fibers from mammalian skeletal muscle

GD Lamb, DG Stephenson - Journal of applied physiology, 2018 - journals.physiology.org
The mechanically skinned (or “peeled”) skeletal muscle fiber technique is a highly versatile
procedure that allows controlled examination of each of the steps in the excitation …

[HTML][HTML] Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and …

RF Capogrosso, P Mantuano… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Muscle fibers lacking dystrophin undergo a long-term alteration of Ca 2+ homeostasis,
partially caused by a leaky Ca 2+ release ryanodine (RyR) channel. S48168/ARM210, an …