An immune response must be tightly controlled so that it will be commensurate with the level
of response needed to protect the organism without damaging normal tissue. The roles of …

Tumor cell metabolism differs from that of normal cells, conferring tumors with metabolic
advantages but affording opportunities for therapeutic intervention. Accordingly, metabolism …

Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation
end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been …

Psychological stress has been recognized as a well-documented risk factor associated with
β2-adrenergic receptor (β2-AR) in the development of pancreatic cancer. Aldo–keto …

Both sunitinib, a multi-target tyrosine kinase inhibitor (TKI) and propranolol, a non-selective
β-blocker, have proven therapeutic effects on malignant melanoma (MM). This study reports …

Long-term nicotine-derived nitrosamine ketone (NNK) and arecoline exposure promotes
carcinogenesis and head and neck squamous cell carcinoma (HNSCC) progression …

The incidence of human papillomavirus-associated head and neck squamous cell
carcinoma (HPV [+] HNSCC) is rapidly increasing. Although clinical management of primary …

Previous studies have shown that the activation of the β2 adrenergic receptor (ADRB2) can
stimulate several signaling pathways that promote tumor growth and metastasis. β …

During cancer progression, tumor cells interact with the neighboring environment, including
neuronal tissue. The important influence of the nervous system on growth and metastasis of …

Background Safety profile of the interaction between anticancer drugs and radiation is a
recurrent question. However, there are little data regarding the non-anticancer treatment …