In contrast to ordinary polymers, the vast majority of biological macromolecules adopt highly
ordered three-dimensional structures that define their functions. The key to folding of a …

Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

Histone tails harbor a plethora of post-translational modifications that direct the function of
chromatin regulators, which recognize them through effector domains. Effector …

Background Controlled modulation of nucleosomal DNA accessibility via post-translational
modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs …

While nucleosomes are highly stable structures as fundamental units of chromatin, they also
slide along the DNA, either spontaneously or by active remodelers. Here, we investigate the …

In eukaryotes, variants of core histone H2A are selectively incorporated in distinct functional
domains of chromatin and are distinguished by conserved sequences of their C-terminal tail …

Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic
genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP …

Ultraviolet (UV) light-induced mutations are unevenly distributed across skin cancer
genomes, but the molecular mechanisms responsible for this heterogeneity are not fully …

ATP-dependent chromatin remodelers are molecular machines that control genome
organization by repositioning, ejecting, or editing nucleosomes, activities that confer them …

The nucleosome core particle (NCP) is the basic packaging unit of DNA. Recently reported
structures of the NCP suggest that the histone octamer undergoes conformational changes …