The NLRP3 inflammasome in acute myocardial infarction

S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

S Toldo, AG Mauro, Z Cutter… - American Journal of …, 2018 - journals.physiology.org
Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges

S Huang, NG Frangogiannis - British journal of pharmacology, 2018 - Wiley Online Library
In the infarcted heart, the damage‐associated molecular pattern proteins released by
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …

Cardiovascular magnetic resonance in acute st-segment–elevation myocardial infarction: Recent advances, controversies, and future directions

H Bulluck, R Dharmakumar, AE Arai, C Berry… - Circulation, 2018 - Am Heart Assoc
Although mortality after ST-segment elevation myocardial infarction (MI) is on the decline,
the number of patients developing heart failure as a result of MI is on the rise. Apart from …

Interleukin-1 blockade in cardiovascular diseases: a clinical update

LF Buckley, A Abbate - European heart journal, 2018 - academic.oup.com
Abstract Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated
as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical …

Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury

DJ Cao, GG Schiattarella, E Villalobos, N Jiang… - Circulation, 2018 - Am Heart Assoc
Background: Myocardium irreversibly injured by ischemic stress must be efficiently repaired
to maintain tissue integrity and contractile performance. Macrophages play critical roles in …

Цитокины в патогенезе и лечении заболеваний человека

АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

[HTML][HTML] Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

SJ Lee, C Lee, S Kang, I Park, YH Kim… - The Journal of …, 2018 - Am Soc Clin Investig
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular
destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its …

Therapeutic use of stem cells for myocardial infarction

M Madigan, R Atoui - Bioengineering, 2018 - mdpi.com
Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although
medical and surgical treatments can significantly improve patient outcomes, no treatment …

Prognostic significance of remote myocardium alterations assessed by quantitative noncontrast T1 mapping in ST-segment elevation myocardial infarction

SJ Reinstadler, T Stiermaier, J Liebetrau… - JACC: cardiovascular …, 2018 - jacc.org
Objectives: This study assessed the prognostic significance of remote zone native T1
alterations for the prediction of clinical events in a population with ST-segment elevation …