Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the
spacial and temporal organization of the densely packed intracellular environment. This …

Mutations in the LMNA gene, which encodes for the nuclear lamina proteins lamins A and C,
are responsible for a diverse group of diseases known as laminopathies. One type of …

Integrator (INT) is a transcriptional regulatory complex associated with RNA polymerase II
that is required for the 3′-end processing of both UsnRNAs and enhancer RNAs. Integrator …

The cell nucleus is nonrandomly organized and lacks defining internal membranes. As such,
prominent domains composed of DNA, RNA, and protein complexes within the nucleus are …

Nuclear bodies are RNA-rich membraneless organelles in the cell nucleus that concentrate
specific sets of nuclear proteins and RNA–protein complexes. Nuclear bodies such as the …

It remains challenging to identify all parts of the nuclear genome that are in proximity to
nuclear speckles, due to physical separation between the nuclear speckle cores and …

The nucleolus is a dynamic subnuclear compartment that has a number of different
functions, but its primary role is to coordinate the production and assembly of ribosomes. For …

The survival of motor neuron (SMN) protein plays an essential role in the biogenesis of
spliceosomal snRNPs and the molecular assembly of Cajal bodies (CBs). Deletion of or …

C3G (Crk SH3 domain binding guanine nucleotide releasing factor)(Rap guanine nucleotide
exchange factor 1), essential for mammalian embryonic development, is ubiquitously …

The nucleus must simultaneously orchestrate DNA replication, transcription, splicing,
signalling, and directional transport of proteins into the nucleus and RNA out of the nucleus …