The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Senior people constitute the fastest growing segment of the population. The elderly are at
risk for malnutrition, thought to be caused by reduced food intake or involution of the …

Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells,
leading to insufficient production of insulin and development of hyperglycemia. Serum …

Pharmacologic expansion of endogenous β cells is a promising therapeutic strategy for
diabetes. To elucidate the molecular pathways that control β-cell growth we screened∼ …

Abstract Purpose of Review To explore the impact of age on type 1 diabetes (T1D)
pathogenesis. Recent Findings Children progress more rapidly from autoantibody positivity …

Unresolved ER stress followed by cell death is recognized as the main cause of a multitude
of pathologies including neonatal diabetes. A systematic analysis of the mechanisms of β …

Hippo signaling is an evolutionarily conserved pathway that critically regulates development
and homeostasis of various tissues in response to a wide range of extracellular and …

Background and aims Abnormal glucagon secretion and functional alterations of the
exocrine pancreas have been described in patients with type 1 diabetes (T1D), but their …

Diabetes mellitus results from disturbed glucose homeostasis due to an absolute (type 1) or
relative (type 2) deficiency of insulin, a peptide hormone almost exclusively produced by the …