Piperlongumine (piplartine) as a lead compound for anticancer agents–Synthesis and properties of analogues: A mini-review

K Piska, A Gunia-Krzyżak, P Koczurkiewicz… - European journal of …, 2018 - Elsevier
Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L.(long
piper), a medical plant known from Ayurvedic medicine. Although was discovered well over …

Piperine as a potential anti-cancer agent: a review on preclinical studies

A Manayi, SM Nabavi, WN Setzer… - Current medicinal …, 2018 - ingentaconnect.com
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in
black pepper and some other Piper species. We attempted to summarize acquired data that …

[HTML][HTML] Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells

AAA Khamis, EMM Ali, MA Abd El-Moneim… - Biomedicine & …, 2018 - Elsevier
Despite advances in cancer treatment, breast cancer remains one of the main life
threatening diseases in women. Most anti-breast cancer drugs cause severe health …

Multi-target cinnamic acids for oxidative stress and inflammation: Design, synthesis, biological evaluation and modeling studies

E Pontiki, D Hadjipavlou-Litina - Molecules, 2018 - mdpi.com
Inflammation is a complex phenomenon that results as a healing response of organisms to
different factors, exerting immune signaling, excessive free radical activity and tissue …

Diet therapy for cancer prevention and treatment based on traditional Persian medicine

B Javadi - Nutrition and cancer, 2018 - Taylor & Francis
Cancer is the second leading cause of death with profound socio-economic consequences
worldwide. Growing evidence suggests the crucial role of diet on cancer prevention and …

Th1-biased immunomodulation and in vivo antitumor effect of a novel piperine analogue

J Santos, M Brito, R Ferreira, AP Moura… - International Journal of …, 2018 - mdpi.com
Natural products have an important role as prototypes in the synthesis of new anticancer
drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the …

Antineoplastic actions of cinnamic acids and their dimers in breast cancer cells: a comparative study

M Hunke, W Martinez, A Kashyap, T Bokoskie… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Breast cancer is the second leading cause of cancer-related deaths in US,
which necessitates constant research for medications with minimal adverse effects. The aim …

[HTML][HTML] Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models

J Mohammad, H Dhillon, S Chikara, S Mamidi… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to a late
diagnosis and poor response to available treatments. There is a need to identify …

Cytotoxic and antiproliferative activity of kanchnar guggulu, an Ayurvedic formulation

P Tomar, YN Dey, D Sharma, MM Wanjari… - Journal of Integrative …, 2018 - Elsevier
Objective Kanchnar guggulu is a compound Ayurvedic formulation used in clinical practice
for the treatment of benign and malignant tumors. The present study investigates its cytotoxic …

Trypanosoma cruzi: analysis of two different strains after piplartine treatment

GAL Vieira, MTA Silva, LO Regasini… - Brazilian Journal of …, 2018 - SciELO Brasil
The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects
through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious …