Microglia–neuron signalling in the spinal cord is a key mediator of mechanical allodynia
caused by peripheral nerve injury. We recently reported sex differences in microglia in pain …

Neuropathic pain after spinal cord injury (SCI) is developed in about 80% of SCI patients
and there is no efficient therapeutic drug to alleviate SCI-induced neuropathic pain. Here we …

Spinal cord injury (SCI) is a debilitating condition in which inflammatory responses in the
secondary phase of injury leads to long lasting sensory-motor dysfunction. The medicinal …

Oxaliplatin therapy of colorectal cancer induces a dose-dependent neuropathic syndrome in
50% of patients. Pharmacological treatments may offer limited relief; scientific efforts are …

Systemic fentanyl induces hyperalgesic priming, long-lasting neuroplasticity in nociceptor
function characterized by prolongation of inflammatory mediator hyperalgesia. To evaluate …

Abstract NLX-112 (aka F13640 or befiradol) possesses marked activity in a variety of animal
models of pain and of neuropsychiatric disorders; it exhibits nanomolar affinity, exceptional …

Neuropathic pain (NP) is a type of chronic pain that is different from the common type of
pain. The mechanisms of NP are still poorly understood. Exploring the key genes and …

NYX-2925 [(2S, 3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2, 5-diazaspiro [3.4] octan-2-yl)
butanamide] is a novel N-methyl-d-aspartate (NMDA) receptor modulator that is currently …

Repeated stimulation of mu-opioid receptors (MORs), by an MOR-selective agonist DAMGO
induces type II priming, a form of nociceptor neuroplasticity, which has 2 components: opioid …

The present study evaluated the possible antiallodynic effect induced by [6]‐gingerol in rats
with L5–L6 spinal nerve ligation (SNL). Moreover, we determined the possible mechanism …