AMPK (5'-adenosine monophosphate-activated protein kinase) is heavily involved in
skeletal muscle metabolic control through its regulation of many downstream targets …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Cellular homeostasis is coordinated through communication between mitochondria and the
nucleus, organelles that each possess their own genomes. Whereas the mitochondrial …

Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas
brown adipose tissue (BAT), which is specialized in dissipating energy through …

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2)
inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular …

The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …

Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly
being investigated for its therapeutic potential in diseases where AMPK hyperactivity results …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is
characterized by the accumulation of intracellular α-synuclein aggregates and the …

The growing evidence of the involvement of purine compounds in signaling, of nucleotide
imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light …

Mitochondrial diseases may result from mutations in the maternally-inherited mitochondrial
DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi …