The gut microbiota plays a fundamental role on the education and function of the host
immune system. Immunological dysregulation is the cause of numerous human disorders …

Methods We conducted a retrospective cohort study of RA patients seen at routine clinic
visits at an academic medical center, 2012–2015. We included patients who had≥ 2 clinical …

Objective Because of its association with joint destruction, anti–citrullinated protein antibody
(ACPA)–positive rheumatoid arthritis (RA) is considered to be more severe than ACPA …

HLA associations, T cell receptor (TCR) repertoire bias, and sex bias have independently
been shown for many diseases. While some immunological differences between the sexes …

The epidemiology of autoimmune diseases is characterized by a significant sex dimorphism,
with the majority of disorders being more prevalent in women. In a parallel fashion, the …

Objectives There is limited information on the epidemiology and treatment patterns of
rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe the …

Background Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid
arthritis (RA). However, approximately one quarter of patients discontinue MTX within 12 …

Abstract Background Prostaglandin E 2 (PGE 2) acts via its EP4 receptor as a cytokine
amplifier (eg, interleukin [IL]-6) and induces the differentiation and expansion of …

Background: There are few data on the epidemiology, clinical manifestations and
management of RA in Brazil, even with the recognition of the high direct, indirect and …

Objective To identify risk factors for large‐joint surgery (LJS) versus small‐joint surgery
(SJS) in rheumatoid arthritis (RA) and evaluate trends in surgery rates over time. Methods A …