Opioids were one of the earliest classes of medications used for pain across a variety of
conditions, but morbidity and mortality have been increasingly associated with their chronic …

Objectives the objectives of this review were (1) to assess whether interventions to support
effective communication between maternity care staff and healthy women in labour with a …

Highlights•Sex and gender influence assessment, attribution and dismissal of
pain.•Differences have been identified in the activity of immune cells in pain …

This paper presents an overview of dental disciplines involved in the treatment of orofacial
pain, temporomandibular disorders (TMD), and occlusion and provides an evidence-based …

2. Methods To obtain a list of original studies reporting genetic association or linkage
analysis with neuropathic pain conditions, we used the search method described in Ref …

It is well established that FKBP51 regulates the stress system by modulating the sensitivity of
the glucocorticoid receptor to stress hormones. Recently, we have demonstrated that …

Migraine is a common and disabling neurological disorder, with a significant socioeconomic
burden. Its pathophysiology involves abnormalities in complex neuronal networks …

Neuropathic pain represents a significant clinical problem because it is a chronic condition
often refractory to available therapy. Therefore, there is still a strong need for new …

Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia,
and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like …

Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the
expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 …