Objectives To develop a population pharmacokinetic (PK) model for vancomycin in Chinese
neonates and infants less than 2 months of age (young infants) with a wide gestational age …

Vancomycin pharmacokinetic (PK) and pharmacodynamic (PD) data in neonates are based
on total concentrations. However, only unbound vancomycin is pharmacologically active …

Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those
involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious …

Valproic acid (VPA) is a first-line anti-epileptic drug that is used in the treatment of
generalized and partial seizures. Gene variants had been proved to influence the …

Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries
where malaria is endemic. However, pediatric doses are largely based on a linear …

The main goal of our study was to characterize the population pharmacokinetics of
vancomycin in critically ill Chinese neonates to develop a pharmacokinetic model and …

Vancomycin, a glycopeptide antibiotic for the treatment of grampositive infections, is mainly
eliminated via glomerular filtration. Thus, its therapeutic effects are affected predominantly …

Purpose: The aim of this study was to evaluate the influence of age and other possible
covariates on vancomycin clearance in order to define a possible cut off value of age for …

Background and Objective A simple approach is proposed to predict drug clearance in
children when no paediatric data are available for drugs metabolised by cytochromes …

Objective: This study was conducted to develop a population pharmacokinetic (PK) model of
levetiracetam in Korean neonates with seizures. Materials and methods: Data were obtained …