Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to
abnormal accumulation of the key effector β-catenin. Over the past decades, a number of …

RAS proteins are small GTPases that regulate signalling networks that control cellular
proliferation and survival. They are frequently mutated in cancer and a commonly occurring …

We performed an extensive immunogenomic analysis of more than 10,000 tumors
comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer …

UCSC Xena is a visual exploration resource for both public and private omics data,
supported through the web-based Xena Browser and multiple turn-key Xena Hubs. This …

Summary Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast
cancer; however, drug resistance is frequently encountered and poorly understood. We …

The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …

Understanding metabolic dysregulation in different disease settings is vital for the safe and
effective incorporation of metabolism-targeted therapeutics in the clinic. Here, using …

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression.
Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation …

Precision oncology uses genomic evidence to match patients with treatment but often fails to
identify all patients who may respond. The transcriptome of these" hidden responders" may …

Mechanistic models are essential to deepen the understanding of complex diseases at the
molecular level. Nowadays, high-throughput molecular and phenotypic characterizations …