Advances in biomaterials for drug delivery are enabling significant progress in biology and
medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

The development of clinically viable delivery methods presents one of the greatest
challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here …

Dysfunctional endothelium causes more disease than any other cell type. Systemically
administered RNA delivery to nonliver tissues remains challenging, in large part because …

As a new class of organic optical nanomaterials, semiconducting polymer nanoparticles
(SPNs) have the advantages of excellent optical properties, high photostability, facile …

Although mRNA and siRNA have significant therapeutic potential, their simultaneous
delivery has not been previously explored. To facilitate the treatment of diseases associated …

Previous studies have identified relevant genes and signalling pathways that are hampered
in human disorders as potential candidates for therapeutics. Developing nucleic acid-based …

Little is known about the metabolism of quiescent endothelial cells (QECs). Nonetheless,
when dysfunctional, QECs contribute to multiple diseases. Previously, we demonstrated that …

Abstract mRNA‐mediated protein replacement represents a promising concept for the
treatment of liver disorders. Children born with fumarylacetoacetate hydrolase (FAH) …

The surface of endothelial cells is covered with cell adhesion molecules, including E‐
selectin, intercellula adhesion molecule 1 (ICAM‐1), and vascular cell adhesion molecule 1 …