Serum chloride levels in critical illness—the hidden story

CA Pfortmueller, D Uehlinger, S von Haehling… - Intensive care medicine …, 2018 - Springer
Chloride is the principal anion of the extracellular fluid and vital for both serum
electroneutrality and acid-base homeostasis. The aim of this review is to investigate the …

Ion channels in drug discovery and safety pharmacology

P Imbrici, O Nicolotti, F Leonetti, D Conte… - … : Methods and Protocols, 2018 - Springer
Ion channels are membrane proteins involved in almost all physiological processes,
including neurotransmission, muscle contraction, pace-making activity, secretion, electrolyte …

[HTML][HTML] Insights into channel dysfunction from modelling and molecular dynamics simulations

M Musgaard, T Paramo, L Domicevica, OJ Andersen… - …, 2018 - Elsevier
Developments in structural biology mean that the number of different ion channel structures
has increased significantly in recent years. Structures of ion channels enable us to …

Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in …

A Sebastian, L Cordain, L Frassetto, T Banerjee… - Medical …, 2018 - Elsevier
We hypothesize that the major environmental determinant of the expression of essential
hypertension in America and other Westernized countries is dietary imprudence in respect of …

Chloride intracellular channel 4 overexpression in the proximal tubules of kidneys from the spontaneously hypertensive rat: insight from proteomic analysis

D Hatziioanou, G Barkas, E Critselis, J Zoidakis… - Nephron, 2018 - karger.com
Background: Hypertensive nephropathy, a leading cause of declining kidney function, is a
multifactorial process not well understood. In order to elucidate biological processes and …

Symbiosal® and lowering of blood pressure and reduced risk of hypertension: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

EFSA Panel on Dietetic Products, Nutrition and … - EFSA …, 2018 - Wiley Online Library
Following an application from Han‐Biotech GmbH, submitted for authorisation of a health
claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of …

SCIENTIFIC OPINION

D Turck, J Castenmiller, S De Henauw, KI Hirsch-Ernst… - 2018 - aura.abdn.ac.uk
Following two requests from the European Commission (EC), the EFSA Panel on Nutrition,
Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the …