The regulation of autophagy by calcium signals: Do we have a consensus?
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
PLCγ1: potential arbitrator of cancer progression
Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple
cellular processes by generating bioactive molecules such as inositol-1, 4, 5-triphosphate …
cellular processes by generating bioactive molecules such as inositol-1, 4, 5-triphosphate …
[HTML][HTML] IP3 receptors preferentially associate with ER-lysosome contact sites and selectively deliver Ca2+ to lysosomes
P Atakpa, NB Thillaiappan, S Mataragka, DL Prole… - Cell reports, 2018 - cell.com
Summary Inositol 1, 4, 5-trisphosphate (IP 3) receptors (IP 3 Rs) allow extracellular stimuli to
redistribute Ca 2+ from the ER to cytosol or other organelles. We show, using small …
redistribute Ca 2+ from the ER to cytosol or other organelles. We show, using small …
[HTML][HTML] TOM70 sustains cell bioenergetics by promoting IP3R3-mediated ER to mitochondria Ca2+ transfer
The mitochondrial translocase of the outer membrane (TOM) is a protein complex that is
essential for the post-translational import of nuclear-encoded mitochondrial proteins. Among …
essential for the post-translational import of nuclear-encoded mitochondrial proteins. Among …
All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics
Inositol 1, 4, 5-trisphosphate (IP3) evokes Ca2+ release through IP3 receptors (IP3Rs) to
generate both local Ca2+ puffs arising from concerted openings of clustered IP3Rs and cell …
generate both local Ca2+ puffs arising from concerted openings of clustered IP3Rs and cell …
Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29
H Ando, M Hirose, K Mikoshiba - Proceedings of the …, 2018 - National Acad Sciences
Spinocerebellar ataxia type 29 (SCA29) is autosomal dominant congenital ataxia
characterized by early-onset motor delay, hypotonia, and gait ataxia. Recently …
characterized by early-onset motor delay, hypotonia, and gait ataxia. Recently …
[HTML][HTML] Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating
Abstract Inositol-1, 4, 5-trisphosphate receptors (InsP3Rs) are cation channels that mobilize
Ca2+ from intracellular stores in response to a wide range of cellular stimuli. The paradigm …
Ca2+ from intracellular stores in response to a wide range of cellular stimuli. The paradigm …
All three IP3 receptor subtypes generate Ca2+ puffs, the universal building blocks of IP3-evoked Ca2+ signals
S Mataragka, CW Taylor - Journal of cell science, 2018 - journals.biologists.com
All three subtypes of inositol 1, 4, 5-trisphosphate receptor (IP3R) are intracellular Ca2+
channels that are co-regulated by IP3 and Ca2+. This allows IP3Rs to evoke regenerative …
channels that are co-regulated by IP3 and Ca2+. This allows IP3Rs to evoke regenerative …
[HTML][HTML] Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells
SK Joseph, MP Young, K Alzayady, DI Yule… - Journal of Biological …, 2018 - ASBMB
A sensitization of inositol 1, 4, 5-trisphosphate receptor (IP 3 R)–mediated Ca 2+ release is
associated with oxidative stress in multiple cell types. These effects are thought to be …
associated with oxidative stress in multiple cell types. These effects are thought to be …
[HTML][HTML] Pathophysiological consequences of isoform-specific IP3 receptor mutations
M Kerkhofs, B Seitaj, H Ivanova, G Monaco… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Ca 2+ signaling governs a diverse range of cellular processes and, as such, is subject to
tight regulation. A main component of the complex intracellular Ca 2+-signaling network is …
tight regulation. A main component of the complex intracellular Ca 2+-signaling network is …