Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains
one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell …

Vaccines and antimicrobial drugs both impose strong selection for resistance. Yet only drug
resistance is a major challenge for 21st century medicine. Why is drug resistance ubiquitous …

Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis.
However, after the introduction of the whole-cell pertussis vaccine (wP), the annual …

One reason for increased pertussis incidence is the adaptation of Bordetella pertussis to
vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV …

There is a lack of insight into the basic mechanisms by which Bordetella pertussis adapts to
the local host environment during infection. We analyzed B. pertussis gene expression in the …

Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence
in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here …

Bordetella pertussis causes whooping cough. The predominant strains in Australia changed
to single nucleotide polymorphism (SNP) cluster I (pertussis toxin promoter allele …

The reemergence of pertussis or whooping cough in several countries highlights the need
for better vaccines. Acellular pertussis vaccines (aPV) contain alum as the adjuvant and …

Background: Despite universal immunization programs, pertussis remains a major public
health concern. This study aimed to describe the pertussis epidemiology in the Puglia region …

Pertussis or whooping cough is currently the most prevalent vaccine-preventable childhood
disease despite> 85% global vaccination coverage. In recent years incidence has greatly …