While the theory of protein folding is well developed, including concepts such as rugged
energy landscape, folding funnel, etc., the same degree of understanding has not been …

Over the past two decades, two-dimensional infrared (2D IR) spectroscopy has evolved from
the theoretical underpinnings of nonlinear spectroscopy as a means of investigating detailed …

Molecular dynamics (MD) simulations of peptides and proteins offer atomic-level detail into
many biological processes, although the degree of insight depends on the accuracy of the …

SNARE proteins constitute the core of the exocytotic membrane fusion machinery. Fusion
occurs when vesicle‐associated and target membrane‐associated SNARE s zipper into …

A central goal of protein-folding theory is to predict the stochastic dynamics of transition
paths—the rare trajectories that transit between the folded and unfolded ensembles—using …

Nanosecond laser temperature jumps with tryptophan fluorescence detection and molecular
dynamics simulation with kinetic dimensionality reduction were used to study the helix–coil …

Coarse-grained molecular simulation models can provide significant insight into the
complex behavior of protein systems, but suffer from an inherently distorted description of …

Coarse-grained molecular simulation models have provided immense, often general, insight
into the complex behavior of condensed-phase systems but suffer from a lost connection to …

One of the most common fundamental secondary-structure elements of proteins is the β-
sheet. Folding of β-sheets into various structures, eg, β-hairpins, β-barrels, and amyloids, is …

Proteine sind in allen Zellen von Lebewesen enthalten und führen hier die verschiedensten
Funktionen des Lebens aus. Damit jedes Protein seine spezielle Aufgabe wahrnehmen …