Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

To facilitate clinical trials of disease-modifying therapies for Alzheimer's disease, which are
expected to be most efficacious at the earliest and mildest stages of the disease,, supportive …

Importance Biomarker testing for asymptomatic, preclinical Alzheimer disease (AD) is
invasive and expensive. Optical coherence tomographic angiography (OCTA) is a …

Background Imaging agents capable of quantifying the brain's tau aggregates will allow a
more precise staging of Alzheimer's disease (AD). The aim of the present study was to …

Introduction Klunk et al. recently proposed a means of standardizing quantitation of amyloid
burden from positron emission tomography scans to a common Centiloid scale, and we …

Objective To assess whether global or regional changes in amyloid burden over 4 years
predict early declines in episodic memory in initially amyloid-negative adults. Methods One …

Importance Older age, high levels of β-amyloid (Aβ), and the presence of the apolipoprotein
E (APOE) ε4 allele are risk factors for Alzheimer disease (AD). However, the extent to which …

Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders.
Successful use of this tool is limited by the lack of a common standard in the quantification of …

PET imaging of tau pathology in Alzheimer disease may benefit from the use of white matter
reference regions. These regions have shown reduced variability compared with …