INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

Transcriptional programs instruct the generation and maintenance of diverse subtypes of
neural cells, establishment of distinct brain regions, formation and function of neural circuits …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Post-mortem tissues samples are a key resource for investigating patterns of gene
expression. However, the processes triggered by death and the post-mortem interval (PMI) …

Brain-derived neurotrophic factor (Bdnf) transcription is controlled by several promoters,
which drive expression of multiple transcripts encoding an identical protein. We previously …

Background Mechanistic understanding of tendon molecular and cellular biology is crucial
toward furthering our abilities to design new therapies for tendon and ligament injuries and …

Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset
hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting …

Recent large-scale genomics efforts have better characterized the molecular correlates of
schizophrenia in postmortem human neocortex, but not hippocampus which is a brain …

Schizophrenia is a disabling disease impacting millions of people around the world, for
which there is no known cure. Current antipsychotic treatments for schizophrenia mainly …