Epidemiological evidence suggests that the incidence of ischaemic stroke in young adults
(18–50 years) has increased substantially. These patients have a long life expectancy after …

The use of evidence from clinical trials to support decisions for individual patients is a form of
“reference class forecasting”: implicit predictions for an individual are made on the basis of …

Background Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined
source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation …

Background We conducted a systematic review and meta‐analysis of randomized controlled
trials (RCT s) comparing patent foramen ovale (PFO) closure, anticoagulation, and …

Stroke is the fifth-most common cause of death and the leading cause of preventable adult
disability in the United States. 1 In 2013, there were 6.5 million stroke-related deaths …

PFOs can be detected by transthoracic echocardiography, TEE, or transcranial Doppler
ultrasound (TCD). Of these tests, transthoracic echocardiography is the least sensitive …

A patent foramen ovale (PFO) is a highly prevalent finding in cryptogenic ischaemic stroke,
particularly in young adults. A common challenge in clinical practice is to distinguish …

Background: New evidence emerged recently regarding the percutaneous closure of patent
foramen ovale (PFO) to prevent recurrent stroke in patients with cryptogenic stroke. Purpose …

Background: The optimal strategy of secondary stroke prevention in patients with patent
foramen ovale (PFO) is controversial. This study was performed to evaluate the efficacy and …

Aims: The aim of this study was to assess the efficacy of a novel percutaneous “deviceless”
suture-mediated patent foramen ovale (PFO) closure system. Methods and results: Between …