The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to
the corresponding amides using oxygen as an oxidant. This visible-light-mediated …

Chalcone, a natural structure, demonstrates many pharmacological activities including
anticancer, and one promising mechanism is to modulate the generation of ROS. It has been …

The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although
traditionally associated with analgesic activity, recent studies have shown that capsaicin has …

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include
most US Food and Drug Administration approved plant derived anti-cancer agents …

Abstract β‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of
medicinal properties and is found in several commercial drugs, such as tadalafil …

To explore antitumor agents with high efficiency and selectivity, two series of 16 H 2 S
donating evodiamine derivatives 8–12 were synthesized and characterized by 1 H NMR, 13 …

Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient
functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to …

The one-pot total synthesis of evodiamine and its analogues is achieved using a three-
component reaction. Through continuous biscyclization, various readily available substrates …