Avian bioreactor systems: a review

RM Woodfint, E Hamlin, K Lee - Molecular biotechnology, 2018 - Springer
Animal bioreactors are genetically modified animal systems that have the potential to reduce
production cost, and improve production efficiency, of pharmaceutically relevant …

New mammalian expression systems

J Zhu, D Hatton - … and Manufacturing of Recombinant Antibodies and …, 2018 - Springer
There are an increasing number of recombinant antibodies and proteins in preclinical and
clinical development for therapeutic applications. Mammalian expression systems are key to …

Influence of cell morphology on mesenchymal stem cell transfection

Y Yang, X Wang, X Hu, N Kawazoe… - … applied materials & …, 2018 - ACS Publications
Gene transfection has broad applications in bioengineering and biomedical fields. Although
many gene carrier materials and transfection methods have been developed, it remains …

The transgenic chicken derived anti-CD20 monoclonal antibodies exhibits greater anti-cancer therapeutic potential with enhanced Fc effector functions

YM Kim, JS Park, SK Kim, KM Jung, YS Hwang, M Han… - Biomaterials, 2018 - Elsevier
Modern genetic techniques, enable the use of animal bioreactor systems for the production
and functional enhancement of anti-cancer antibodies. Chicken is the most efficient animal …

A novel recombinant human plasminogen activator: Efficient expression and hereditary stability in transgenic goats and in vitro thrombolytic bioactivity in the milk of …

Z He, R Lu, T Zhang, L Jiang, M Zhou, D Wu… - PLoS One, 2018 - journals.plos.org
Background Thromboses is a rapidly growing medical problem worldwide. Low-cost, high-
scale production of thrombotic drugs is needed to meet the demand. The production of …

Production of functional human CuZn-SOD and EC-SOD in bitransgenic cloned goat milk

R Lu, T Zhang, D Wu, Z He, L Jiang, M Zhou… - Transgenic …, 2018 - Springer
Human copper/zinc superoxide dismutase (CuZn-SOD) and extracellular superoxide
dismutase (EC-SOD) are two superoxide dismutases that scavenge reactive oxygen species …

Efficient increase of the novel recombinant human plasminogen activator expression level and stability through the use of homozygote transgenic rabbits

Z He, L Jiang, T Zhang, M Zhou… - International …, 2018 - spandidos-publications.com
Expression efficacy of recombinant protein in current expression systems is generally low.
Therefore, the expression levels of recombinant proteins in the breast milk of transgenic …

Genome editing: state of the art and application to animal husbandry.

NA Zinovieva, NA Volkova, VA Bagirov - 2018 - cabidigitallibrary.org
The creation and development of genome editing (GE) technologies open new opportunities
in the genetic engineering of domestic mammals and poultry. In the present review, we have …

Delipidation of plasma has minimal effects on human butyrylcholinesterase

S Onder, O Tacal, O Lockridge - Frontiers in Pharmacology, 2018 - frontiersin.org
Human butyrylcholinesterase (BChE) is purified in large quantities from Cohn fraction IV-4 to
use for protection against the toxicity of chemical warfare agents. Small scale preliminary …

Геномное редактирование: современное состояние исследований и применение в животноводстве

НА Зиновьева, НА Волкова, ВА Багиров - Биотехнология, 2018 - elibrary.ru
Создание и развитие технологий геномного редактирования (GE) открывает новые
возможности в генетической инженерии домашних млекопитающих и птиц. В …