[HTML][HTML] Role of C-reactive protein at sites of inflammation and infection

NR Sproston, JJ Ashworth - Frontiers in immunology, 2018 - frontiersin.org
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

[HTML][HTML] Mechanisms in hypertension and target organ damage: Is the role of the thymus key?

X Dai, L Hua, Y Chen, J Wang, J Li… - International …, 2018 - spandidos-publications.com
A variety of cells and cytokines have been shown to be involved in the whole process of
hypertension. Data from experimental and clinical studies on hypertension have confirmed …

[HTML][HTML] Responses of endothelial cells towards ischemic conditioning following acute myocardial infarction

S Hernández-Reséndiz, M Muñoz-Vega… - Conditioning …, 2018 - ncbi.nlm.nih.gov
One of the primary therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial infarct size and optimizing cardiac function following acute …

CRP stimulates GDF15 expression in endothelial cells through p53

Y Kim, N Noren Hooten, MK Evans - Mediators of inflammation, 2018 - Wiley Online Library
Growth differentiation factor 15 (GDF15) is a multifunctional, secreted protein that is a direct
target gene of p53. GDF15 is a prospective biomarker of cardiovascular disease (CVD). C …

[HTML][HTML] Targeting inflammation in the prevention and treatment of type 2 diabetes: insights from CANTOS

S Verma, V Mathew, ME Farkouh - Journal of the American College of …, 2018 - jacc.org
The statistics of the burgeoning epidemic of diabetes paint an austere picture—425 million
people worldwide have diabetes mellitus, and this number is expected to increase to 629 …

High intraperitoneal interleukin-6 levels predict peritonitis in peritoneal dialysis patients: a prospective cohort study

X Yang, Y Tong, H Yan, Z Ni, J Qian… - American journal of …, 2018 - karger.com
Background: To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing
local subclinical intraperitoneal inflammation for the development of peritonitis in continuous …

Choroidal thickness changes in rheumatoid arthritis and the effects of short-term hydroxychloroquine treatment

O Karti, Z Ayhan, MO Zengin, M Kaya… - Ocular immunology and …, 2018 - Taylor & Francis
Purpose: The objective of this study is to evaluate choroidal thickness (CT) in patients with
rheumatoid artritis (RA) and the effects of short-term hydroxychloroquine (HCQ) treatment …

[HTML][HTML] Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal …

E Sucajtys-Szulc, A Debska-Slizien… - Molecular and cellular …, 2018 - Springer
Inflammation related to chronic kidney disease (CKD) is an important clinical problem. We
recently determined that hepatocyte nuclear factor 1α (HNF1α) was upregulated in the livers …

CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients

S Kittel-Schneider, M Kaspar, D Berliner… - Brain, Behavior, and …, 2018 - Elsevier
Objective: Heart failure (HF) is a complex medical condition with a multitude of genetic and
other factors being involved in the pathogenesis. Emerging evidence points to an …

Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

S Broadgate, C Kiire, S Halford… - Acta Ophthalmologica, 2018 - Wiley Online Library
Diabetic retinopathy, a complication of both type 1 and type 2 diabetes, is a complex disease
and is one of the leading causes of blindness in adults worldwide. It can be divided into …