The pathogenesis of psoriatic arthritis

DJ Veale, U Fearon - The Lancet, 2018 - thelancet.com
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with
inflammation of the joints and entheses, including those of the axial skeleton, and is …

Pathogenic stromal cells as therapeutic targets in joint inflammation

SG Dakin, M Coles, JP Sherlock, F Powrie… - Nature reviews …, 2018 - nature.com
Abstract Knowledge of how the joint functions as an integrated unit in health and disease
requires an understanding of the stromal cells populating the joint mesenchyme, including …

The oncostatin M‐stromal cell axis in health and disease

NR West, BMJ Owens… - Scandinavian Journal of …, 2018 - Wiley Online Library
The field of stromal immunology has risen to prominence in the last decade, fuelled by
accumulating evidence that nonhaematopoietic mesenchymal cells are not simply involved …

The role of extracellular nucleic acids in rheumatoid arthritis

E Neumann, R Hasseli, U Lange… - Current …, 2018 - ingentaconnect.com
Chronic inflammation, synovial hyperplasia, and local hypoxia lead to synovial cell
activation causing severe joint damage in chronic-inflammatory rheumatoid arthritis (RA) …

AB0138 The bone marrow oedema is linked to a osteoclastic environment in bone marrow during collagen induced mice arthritis development

W Tan, W Xuan, Q Wu, A Luo, W Yan, F Wang - 2018 - ard.bmj.com
Background Bone erosion is a central pathogenic event in Rheumatoid arthritis (RA) and is
associated with joint damage and poor functional outcome. The synovitis is traditionally …

3, 5-Di-C-β-D-glucopyranosyl phloroacetophenone, a major component of Melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse …

HJ Kim, JH Choi, JH Hwang… - International …, 2018 - spandidos-publications.com
Melicope ptelefolia has been traditionally used to treat rheumatism and fever. The present
study aimed to investigate the therapeutic effect of 3, 5‑di‑C‑β‑D‑glucopyranosyl …

Tumour necrosis factor: out of my heart!

L Vereecke, D Elewaut - Annals of the Rheumatic Diseases, 2018 - ard.bmj.com
Increasing evidence points to cardiovascular comorbidities in patients with rheumatic
diseases, particularly in rheumatoid arthritis (RA) and spondyloarthritis (SpA). 1 Ischaemic …

The Role of IL‐6RA in UHMWPE Promotes Proliferation in Fibro‐Like Synovial Cells

X Pang, J Yang, X Zhen, H Nie, H Qin… - BioMed Research …, 2018 - Wiley Online Library
UHMWPE granule could induce macrophages and inflammatory responses in interfacial
tissues, which eliminated the wear debris of UHMWPE component and further induced …

Isolation, characterization and myogenic differentiation of synovial mesenchymal stem cells

F Meligy, D Abdo Elgamal, N Mostafa… - Journal of Medical …, 2018 - journals.ekb.eg
Background: Synovial membrane represents a worthy source of mesenchymal stem cells
(MSCs). Synovial membrane derived stem cells has been described as encouraging line of …

THU0099 Myeloid sirtuin 6 deficiency accelerates experimental and human arthritis by increasing macrophage infiltration into synovium

YS Suh, YH Cheon, MY Kim, SJ Woo, HS Noh, BH Park… - 2018 - ard.bmj.com
Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of the joints
and is characterised by immune cell infiltration, synovial hyperplasia, and destruction of …