Currently, the world is facing the negative impact of global warming on all living beings.
Adverse effects of global warming are also becoming obvious in dairy cattle breeding. In …

Control of DNA methylation level is critical for gene regulation, and the factors that govern
hypomethylation at CpG islands (CGIs) are still being uncovered. Here, we provide evidence …

Background Bisulfite sequencing is widely employed to study the role of DNA methylation in
disease; however, the data suffer from biases due to coverage depth variability. Imputation …

DNA methylation in the germline is among the most important factors influencing the
evolution of mammalian genomes. Yet little is known about its evolutionary rate or the …

Background Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic
variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients …

Abstract Background/Aims: Impaired adipogenesis may be the underlying cause in the
development of obesity and type II diabetes. Mechanistically, the family of Homeobox …

The association between early childhood adversity and later risk of mental disorders is well
established. The mechanisms by which signals from the early environment are transmitted to …

Following erasure in the blastocyst, the entire genome undergoes de novo methylation at
the time of implantation, with CpG islands being protected from this process. This bimodal …

Cancer incidence and mortality increase with increasing body mass index (BMI), but BMI-
associated epigenetic alterations in cancer remain elusive. We hypothesized that BMI would …

Human tumors undergo massive changes in DNA methylation. Recent studies showed that
site-specific methylation of CpG sites is determined by the DNA sequence context …