Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …

Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …

Backgound: The inability to detect premature atherosclerosis significantly hinders
implementation of personalized therapy to prevent coronary heart disease. A …

DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in
development, genomic imprinting, X inactivation, chromosome stability, gene expression …

The incidence of metabolic disorders like type 2 diabetes (T2D) and obesity continue to
increase. Although it is evident that the increasing incidence of diabetes confers a global …

SLE is a complex autoimmune disease that results from the interplay of genetics,
epigenetics and environmental exposures. DNA methylation is an epigenetic mechanism …

We introduce a Bayesian semi-supervised method for estimating cell counts from DNA
methylation by leveraging an easily obtainable prior knowledge on the cell-type composition …

Maternal hyperglycemia during pregnancy is associated with excess fetal growth and
adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may …