Intermediate filaments in cardiomyopathy

M Tsikitis, Z Galata, M Mavroidis, S Psarras… - Biophysical …, 2018 - Springer
Intermediate filament (IF) proteins are critical regulators in health and disease. The
discovery of hundreds of mutations in IF genes and posttranslational modifications has been …

[HTML][HTML] Biomechanical response of skeletal muscle to eccentric contractions

RL Lieber - Journal of sport and health science, 2018 - Elsevier
The forced lengthening of an activated skeletal muscle has been termed an eccentric
contraction (EC). This review highlights the mechanically unique nature of the EC and …

Aberrant mitochondrial fission is maladaptive in desmin mutation–induced cardiac proteotoxicity

S Alam, CS Abdullah, R Aishwarya… - Journal of the …, 2018 - Am Heart Assoc
Background Desmin filament proteins interlink the contractile myofibrillar apparatus with
mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause …

Mitochondria-associated membranes (MAMs): an emerging platform connecting energy and immune sensing to metabolic flexibility

J Rieusset - Biochemical and Biophysical Research …, 2018 - Elsevier
Living organisms have the capacity to sense both nutrients and immune signals in order to
adapt their metabolism to the needs, and both metabolic inflexibility and exacerbated …

Sarcomere structure: the importance of desmin protein in muscle atrophy

G Marzuca-Nassr, KF Vitzel, E Mancilla-Solorza… - 2018 - repositorio.ucm.cl
Knowing the ultrastructure of skeletal muscle is critical to understand how it works under
normal situation and the disorders caused by extreme or pathological conditions. Sarcomere …

The cytoskeleton in the extraocular muscles of desmin knockout mice

MA Rodríguez, JX Liu, K Parkkonen… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: To investigate the effect of absence of desmin on the extraocular muscles (EOMs)
with focus on the structure and composition of the cytoskeleton. Methods: The distribution of …

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

AR O'Rourke, A Lindsay, MD Tarpey, S Yuen… - The FEBS …, 2018 - Wiley Online Library
While α‐actin isoforms predominate in adult striated muscle, skeletal muscle‐specific
knockouts (KOs) of nonmuscle cytoplasmic βcyto‐or γcyto‐actin each cause a mild, but …

Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats

X Xiong, L Han, S Liu, J Miao, M Luo… - Journal of …, 2018 - Wiley Online Library
Music has a long history of healing or mitigating physical and mental illness in the clinical
setting. We aimed to test changes in behavioral cognition and serum proteomics in rats …

[HTML][HTML] Comparative bioinformatics characteristic of bladder cancer stage 2 from stage 4 expression profile: a network-based study

MZ Azodi, MR Tavirani, M Rostami-Nejad… - Galen Medical …, 2018 - ncbi.nlm.nih.gov
Background: Bladder cancer (BC) has remained as one of the most challenging issues in
medicine. The aim of this study was to investigate the differential network analysis of stages …

Nuclear Encoded Mitochondrial Proteins in Metabolite Transport and Oxidation Pathway Connecting Metabolism of Nutrients

J Vašková, J Firment, L Vaško - … Diseases; IntechOpen: London …, 2018 - books.google.com
In the mitochondria, there are ongoing processes essential to the survival of cells associated
with the production of energy ending in the oxidative phosphorylation and the formation of …