The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Reactive oxygen species (ROS) are well-known for playing a dual role as destructive and
constructive species. Indeed, ROS are engaged in many redox-governing activities of the …

Although there has been a renewed interest in the field of cancer metabolism in the last
decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be …

Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular
functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death …

Cancer is the leading cause of death worldwide after cardiovascular diseases. This has
been the case for the last few decades despite there being an increase in the number of …

A general hallmark of neurological diseases is the loss of redox homeostasis that triggers
oxidative damages to biomolecules compromising neuronal function. Under physiological …

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and
antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low …