The delivery of proteins into cells is a potential game changer for a wide array of therapeutic
purposes, including cancer therapy, immunomodulation and treatment of inherited diseases …

Therapeutic proteins have increased dramatically in both number and frequency of use in
recent years, primarily owing to advances in protein engineering. Protein therapy provides …

The human organism and its constituting cells rely on interplay between multiple proteins
exerting specific functions. Progress in molecular biotechnologies has facilitated the …

We present here an integrated nanotechnology/biology strategy for cancer immunotherapy
that uses arginine nanoparticles (ArgNPs) to deliver CRISPR-Cas9 gene editing machinery …

Cordyceps militaris is a well-known edible medicinal mushroom in East Asia that contains
abundant and diverse bioactive compounds. Since traditional genome editing systems in C …

The mitogen-activated protein kinase (MAPK) pathway is frequently aberrantly activated in
advanced cancers, including metastatic prostate cancer (CaP). However, activating …

Virus-mediated expression of defined transcription factor (TF) genes can effectively induce
cellular reprogramming. However, sustained expression of the TFs often hinders pluripotent …

Temporal and spatial regulation of the subcellular distribution of transcriptional regulators is
important to ensure their proper functioning in a cell. Mesoderm induction early response 1 α …

Programmed cell death plays a critical role in host defense against viruses. Infected cells
detect the intruder and execute signaling cascades resulting in cell death, thus thwarting the …

The trace amine–associated receptor 1 (TAAR1) is an intracellular G–protein coupled
receptor whose activation by trace amines, catecholamines and amphetamines leads to …