A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium
tuberculosis, can persist in humans for decades by avoiding clearance from host immunity …

To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell
phenotype, we characterized those host phagocytes that controlled or supported bacterial …

Lipid droplet (LD) formation occurs during infection of macrophages with numerous
intracellular pathogens, including Mycobacterium tuberculosis. It is believed that M …

The finding that the Warburg effect observed in proliferating cancer cells is also observed
during immune responses renewed the interest in the study of metabolic reprogramming of …

Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue
damage associated with many chronic inflammatory disorders. Although foam cell …

Macrophages play a central role in tuberculosis, as the site of primary infection, inducers
and effectors of inflammation, innate and adaptive immunity, as well as mediators of tissue …

Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug
resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of …

Macrophages, being the cornerstone of the immune system, have adapted the ancient
nutrient acquisition mechanism of phagocytosis to engulf various infectious organisms …

Innate immunity relies on the effective recognition and elimination of pathogenic
microorganisms. This entails sequestration of pathogens into phagosomes that promptly …