Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …

Physical forces have a crucial role in tumor progression and cancer treatment. The
application of principles of engineering and physical sciences to oncology has provided …

Abstract Angiotensin-converting enzyme (ACE)—a zinc-dependent dicarboxypeptidase with
two catalytic domains—plays a major part in blood pressure regulation by converting …

Background The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a
milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic …

A solid tumor is like an aberrant organ–comprised of cancer cells and a variety of host cells
embedded in an extracellular matrix–nourished by blood vessels and drained by lymphatic …

Abstract Treatment-related side effects are a major clinical problem in cancer treatment.
They lead to reduced compliance to therapy as well as increased morbidity and mortality …

To decouple the effects of collagen fiber density and network mechanics on cancer cell
behavior, we describe a highly tunable in vitro 3D interpenetrating network (IPN) consisting …

Gliomas are the most common primary intrinsic tumor in the brain and are classified as low-
or high-grade according to the World Health Organization (WHO). Patients with high-grade …

Renin–angiotensin system (RAS) plays an important role in the regulation of blood pressure
and hormonal balance. Using positron emission tomography (PET) technology, it is possible …

Renin-angiotensin system inhibitors (RASi) have shown potential anti-tumor effects that may
have a significant impact in cancer therapy. The components of the renin-angiotensin …