There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour
microenvironment and undergo an activation process associated with secretion of growth …

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …

Obesity increases the risk of multiple gastrointestinal cancers and worsens disease
outcomes. Conversely, strong inverse associations have emerged between physical activity …

Macroautophagy is the process by which cells package and degrade cytosolic components,
and recycle the breakdown products for future use. Since its initial description by Christian …

Here, we wish to propose a new systematic approach to cancer therapy, based on the
targeting of mitochondrial metabolism, especially in cancer stem cells (CSCs). In the future …

Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate
metabolism and associated with poor prognosis in solid tumours including breast cancer …

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common human cancer
and affects approximately 50,000 new patients every year in the US. The major risk factors …

Maintenance of health involves a synchronized network of catabolic and anabolic signals
among organs/tissues/cells that requires differential bioenergetics from mitochondria and …