Automated chemical oligosaccharide synthesis: novel approach to traditional challenges
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …
more accessible. However, many current methods still rely heavily upon specialized …
Toward automated enzymatic synthesis of oligosaccharides
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
Hierarchical and programmable one-pot synthesis of oligosaccharides
The programmable one-pot oligosaccharide synthesis method was designed to enable the
rapid synthesis of a large number of oligosaccharides, using the software Optimer to search …
rapid synthesis of a large number of oligosaccharides, using the software Optimer to search …
Electrochemically switchable ring-opening polymerization of lactide and cyclohexene oxide
An electrochemical method was developed for the redox switchable polymerization of
lactide and cyclohexene oxide. Using a lithium reversible sacrificial electrode and a high …
lactide and cyclohexene oxide. Using a lithium reversible sacrificial electrode and a high …
Direct N‐Glycofunctionalization of Amides with Glycosyl Trichloroacetimidate by Thiourea/Halogen Bond Donor Co‐Catalysis
Y Kobayashi, Y Nakatsuji, S Li, S Tsuzuki… - Angewandte …, 2018 - Wiley Online Library
Using a halogen bond (XB) donor and Schreiner's thiourea as cooperative catalysts, various
amides, including the asparagine residues of several peptides, were directly coupled with …
amides, including the asparagine residues of several peptides, were directly coupled with …
Machine‐driven enzymatic oligosaccharide synthesis by using a peptide synthesizer
For decades, researchers have endeavored to develop a general automated system to
synthesize oligosaccharides that is comparable to the preparation of oligonucleotides and …
synthesize oligosaccharides that is comparable to the preparation of oligonucleotides and …
Carbohydrate‐based vaccines for oncotherapy
MM Wei, YS Wang, XS Ye - Medicinal Research Reviews, 2018 - Wiley Online Library
Cancer is still one of the most serious threats to human worldwide. Aberrant patterns of
glycosylation on the surface of cancer cells, which are correlated with various cancer …
glycosylation on the surface of cancer cells, which are correlated with various cancer …
Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities
NT Chandrika, S Garneau-Tsodikova - Chemical Society Reviews, 2018 - pubs.rsc.org
A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …
A microbial–enzymatic strategy for producing chondroitin sulfate glycosaminoglycans
Z Zhou, Q Li, H Huang, H Wang, Y Wang… - Biotechnology and …, 2018 - Wiley Online Library
Chondroitin sulfate has been widely used in both medical and clinical applications.
Commercial chondroitin sulfate has been mainly acquired from animal tissue extraction …
Commercial chondroitin sulfate has been mainly acquired from animal tissue extraction …
Large scale preparation of high mannose and paucimannose N-glycans from soybean proteins by oxidative release of natural glycans (ORNG)
Y Zhu, M Yan, Y Lasanajak, DF Smith, X Song - Carbohydrate research, 2018 - Elsevier
Despite the important advances in chemical and chemoenzymatic synthesis of glycans,
access to large quantities of complex natural glycans remains a major impediment to …
access to large quantities of complex natural glycans remains a major impediment to …