Variability in analgesic response to non-steroidal anti-inflammatory drugs
KN Theken - Prostaglandins & other lipid mediators, 2018 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used agents
for the treatment of acute and chronic pain. However, it has long been recognized that there …
for the treatment of acute and chronic pain. However, it has long been recognized that there …
Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy
R Benelli, R Venè, N Ferrari - Translational Research, 2018 - Elsevier
A plentiful literature has linked colorectal cancer (CRC) to inflammation and prostaglandin-
endoperoxide synthase (PTGS) 2 expression. Accordingly, several nonsteroidal …
endoperoxide synthase (PTGS) 2 expression. Accordingly, several nonsteroidal …
Association of GPI a and COX‐2 gene polymorphism with aspirin resistance
H Wang, X Sun, W Dong, X Cai, Y Zhou… - Journal of clinical …, 2018 - Wiley Online Library
Objective This study aimed to explore the association between GPI a, COX‐2 gene
polymorphisms and aspirin resistance in the ischemic stroke patients from the southern part …
polymorphisms and aspirin resistance in the ischemic stroke patients from the southern part …
[HTML][HTML] Differential gene expression profiles in peripheral blood in Northeast Chinese Han people with acute myocardial infarction
L Fan, H Meng, X Guo, X Li, F Meng - Genetics and molecular biology, 2018 - SciELO Brasil
This study aimed to use gene chips to investigate differential gene expression profiles in the
occurrence and development of acute myocardial infarction (AMI). The study included 12 …
occurrence and development of acute myocardial infarction (AMI). The study included 12 …
Platelet activation polymorphisms in ischemia
Background: Ischemia is a multifactorial disorder in which several genetic and
environmental factors are involved. Platelets are the major causative agents of this disease …
environmental factors are involved. Platelets are the major causative agents of this disease …
The vascular endothelium
S Moncada - Endothelium and Cardiovascular Diseases, 2018 - Elsevier
For a long time it was believed that the endothelium was just an inert layer covering all
endovascular surfaces. In the last 40 years, research on endothelium has blossomed and its …
endovascular surfaces. In the last 40 years, research on endothelium has blossomed and its …
Genetic variant in the 3′-untranslated region of the COX2 gene is associated with type 2 diabetes: a hospital-based case-control study
Abstract Type 2 diabetes (T2DM) is caused by the decreased β-cell mass and insulin
deficiency, and disease is characterized by hypoglycemia. The insulin resistance also plays …
deficiency, and disease is characterized by hypoglycemia. The insulin resistance also plays …
Pharmacogenetics of stroke
S Ross, G Paré - Stroke, 2018 - Am Heart Assoc
In contrast to the COX-1 enzyme, the COX-2 is an inducible enzyme that is expressed by
inflammation cells, and it is thought to have protective effects because it facilitates the …
inflammation cells, and it is thought to have protective effects because it facilitates the …
[HTML][HTML] Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism
V De Iuliis, S Ursi, A Pennelli, M Caruso… - Prostaglandins & Other …, 2018 - Elsevier
Background In order to better characterize the molecular mechanisms involved in
processing mutated transcripts, we investigated the post-transcriptional role of the C924T …
processing mutated transcripts, we investigated the post-transcriptional role of the C924T …
Coexistence of colorectal adenomas and coronary calcification in asymptomatic men and women
Background: No study has directly compared the risk factors associated with subclinical
coronary atherosclerosis and CRA. Study: This was a cross-sectional study using …
coronary atherosclerosis and CRA. Study: This was a cross-sectional study using …