Precision medicine and radiogenomics in breast cancer: new approaches toward diagnosis and treatment

K Pinker, J Chin, AN Melsaether, EA Morris, L Moy - Radiology, 2018 - pubs.rsna.org
Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of
an individual and, when present, his or her disease. It has a host of targets, including genes …

[HTML][HTML] NeuralNetTools: Visualization and analysis tools for neural networks

MW Beck - Journal of statistical software, 2018 - ncbi.nlm.nih.gov
Supervised neural networks have been applied as a machine learning technique to identify
and predict emergent patterns among multiple variables. A common criticism of these …

Extreme environments and the origins of biodiversity: adaptation and speciation in sulphide spring fishes

M Tobler, JL Kelley, M Plath, R Riesch - Molecular ecology, 2018 - Wiley Online Library
Organisms adapted to physiochemical stressors provide ideal systems to study evolutionary
mechanisms that drive adaptation and speciation. This review study focuses on livebearing …

Institutional and legal context in natural experiments: The case of state antitakeover laws

JM Karpoff, MD Wittry - The Journal of Finance, 2018 - Wiley Online Library
We argue and demonstrate empirically that a firm's institutional and legal context has first‐
order effects in tests that use state antitakeover laws for identification. A priori, the size and …

Development of a preventive HIV vaccine requires solving inverse problems which is unattainable by rational vaccine design

MHV Van Regenmortel - Frontiers in immunology, 2018 - frontiersin.org
Hypotheses and theories are essential constituents of the scientific method. Many
vaccinologists are unaware that the problems they try to solve are mostly inverse problems …

GeneGini: Assessment via the Gini coefficient of reference “housekeeping” genes and diverse human transporter expression profiles

S O'Hagan, MW Muelas, PJ Day, E Lundberg, DB Kell - Cell systems, 2018 - cell.com
The expression levels of SLC or ABC membrane transporter transcripts typically differ 100-to
10,000-fold between different tissues. The Gini coefficient characterizes such inequalities …

Crisis or self-correction: Rethinking media narratives about the well-being of science

KH Jamieson - Proceedings of the National Academy of …, 2018 - National Acad Sciences
After documenting the existence and exploring some implications of three alternative news
narratives about science and its challenges, this essay outlines ways in which those who …

Machine learning provides novel neurophysiological features that predict performance to inhibit automated responses

A Vahid, M Mückschel, A Neuhaus, AK Stock… - Scientific reports, 2018 - nature.com
Neurophysiological features like event-related potentials (ERPs) have long been used to
identify different cognitive sub-processes that may contribute to task performance. It has …

Tumor‐stroma interactions differentially alter drug sensitivity based on the origin of stromal cells

BD Landry, T Leete, R Richards… - Molecular systems …, 2018 - embopress.org
Due to tumor heterogeneity, most believe that effective treatments should be tailored to the
features of an individual tumor or tumor subclass. It is still unclear, however, what …

OnPLS-based multi-block data integration: a multivariate approach to interrogating biological interactions in asthma

SN Reinke, B Galindo-Prieto, T Skotare… - Analytical …, 2018 - ACS Publications
Integration of multiomics data remains a key challenge in fulfilling the potential of
comprehensive systems biology. Multiple-block orthogonal projections to latent structures …