Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic
Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

Cell senescence is an important driver of the ageing process. The accumulation of
senescent cells in tissues is accelerated by stress signals from senescent cells that induce …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …