The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias

MH Sivakumaran, AK Mackenzie, IR Callan, JA Ainge… - Scientific reports, 2018 - nature.com
Translational recognition memory research makes frequent use of the Novel Object
Recognition (NOR) paradigm in which animals are simultaneously presented with one new …

Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage

RN Newsome, AN Trelle, C Fidalgo, B Hong… - Learning & …, 2018 - learnmem.cshlp.org
The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the
anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in …

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model

K Herline, F Prelli, P Mehta, C MacMurray… - Alzheimer's Research & …, 2018 - Springer
Background Alzheimer's disease (AD) is characterized by physiologically endogenous
proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating …

Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age

BA Kent, CJ Heath, CH Kim, R Ahrens… - Brain and …, 2018 - Wiley Online Library
Introduction Tau is a microtubule‐associated binding protein implicated in
neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's …

Midday meals do not impair mouse memory

SC Power, MJ Michalik, S Couture-Nowak, BA Kent… - Scientific Reports, 2018 - nature.com
Nocturnal mice fed in the middle of the light period exhibit food anticipatory rhythms of
behavior and physiology under control of food-entrainable circadian clocks in the brain and …

The Contribution of Recollection, Familiarity and Discrimination to Object Recognition Deficits in Advanced Age

SN Burke, CA Barnes - Handbook of Behavioral Neuroscience, 2018 - Elsevier
Declines in object recognition are widely reported in older humans and animal models, but
the exact nature of these deficits remains a topic of debate. Accumulating data over the past …

The Value of the Object Recognition Paradigm in Investigating Animal Models of Alzheimer's Disease: Advances and Future Directions

C Mathis - Handbook of Behavioral Neuroscience, 2018 - Elsevier
A number of animal models have been designed to reproduce some or the main
pathophysiological and behavioural characteristics of Alzheimer's disease (AD), and to …

Perirhinal cortex lesions and spontaneous object recognition memory in rats: Detecting novelty but not distinguishing novelty

JP Aggleton - Handbook of Behavioral Neuroscience, 2018 - Elsevier
Perirhinal cortex lesions in rats consistently impair object recognition memory, as shown by
the failure to spend more time exploring a novel object in preference to a familiar object in a …

Passive Immunization to Improve Cognition and Reduce Pathological Species in a Mouse Model of Alzheimer's Disease

K Herline - 2018 - search.proquest.com
Alzheimer's disease (AD) is characterized by physiologically endogenous proteins, amyloid
beta (Aβ) and tau, undergoing a conformational change and accumulating as soluble …