Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure

A Pinto-Martinez, V Hernández-Rodríguez… - Experimental …, 2018 - Elsevier
Chagas disease is a neglected tropical affection caused by the protozoan parasite
Trypanosoma cruzi. There is no current effective treatment since the only two available …

Trypanosoma cruzi: death phenotypes induced by ortho-naphthoquinone substrates of the aldo-keto reductase (TcAKR). Role of this enzyme in the mechanism of …

PA Garavaglia, MF Rubio, M Laverrière, LM Tasso… - Parasitology, 2018 - cambridge.org
Several ortho-naphthoquinones (o-NQs) have trypanocidal activity against Trypanosoma
cruzi, the aetiological agent of Chagas disease. Previously, we demonstrated that the aldo …

[PDF][PDF] Estudo do efeito da EGCG in vitro e in vivo, suas associações e mecanismo molecular de ação em Leishmania infantum

JD Inácio Filho - 2018 - arca.fiocruz.br
As leishmanioses são doenças tropicais negligenciadas presentes em 98 países e são
responsáveis pelo acometimento de 1, 6 milhão de novos casos por ano, podendo levar a …