Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
FH Bardai, DG Ordonez, RM Bailey, M Hamm… - PLoS …, 2018 - journals.plos.org
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
Parkinson disease. Genetics and neuropathology link Parkinson disease with the …
Parkinson disease. Genetics and neuropathology link Parkinson disease with the …
Experimental and clinical strategies for treating spinocerebellar ataxia type 3
Z Wang - Neuroscience, 2018 - Elsevier
Abstract Spinocerebellar ataxia type 3 (SCA3), or Machado–Joseph disease (MJD), is an
autosomal dominant neurodegenerative disorder caused by the expansion of a …
autosomal dominant neurodegenerative disorder caused by the expansion of a …
Neuronal-specific impairment of heparan sulfate degradation in Drosophila reveals pathogenic mechanisms for Mucopolysaccharidosis type IIIA
DL Webber, A Choo, LJ Hewson, PJ Trim, MF Snel… - Experimental …, 2018 - Elsevier
Abstract Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder resulting
from the deficit of the N-sulfoglucosamine sulfohydrolase (SGSH) enzyme that leads to …
from the deficit of the N-sulfoglucosamine sulfohydrolase (SGSH) enzyme that leads to …
Sir-2.1 mediated attenuation of α-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans
Misfolding and accumulation of cellular protein aggregates are pathological hallmarks of
aging and neurodegeneration. One such protein is α-synuclein, which when misfolded …
aging and neurodegeneration. One such protein is α-synuclein, which when misfolded …
Divalproex sodium modulates nuclear localization of ataxin‐3 and prevents cellular toxicity caused by expanded ataxin‐3
ZJ Wang, A Hanet, D Weishäupl… - CNS Neuroscience …, 2018 - Wiley Online Library
Summary Background & Aims Spinocerebellar ataxia type 3 (SCA 3), also known as
Machado‐Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative …
Machado‐Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative …
Drosophila as a Neurotoxicological Model
Drosophila melanogaster is a powerful model genetic system widely used for a variety of
neurobiological and developmental studies. Its use for neurotoxicological experiments has …
neurobiological and developmental studies. Its use for neurotoxicological experiments has …