Immunotherapeutic interventions of triple negative breast cancer
Abstract Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast
cancer that lacks the expression of oestrogen receptors, progesterone receptors and human …
cancer that lacks the expression of oestrogen receptors, progesterone receptors and human …
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
[HTML][HTML] Predicting potential drugs for breast cancer based on miRNA and tissue specificity
L Yu, J Zhao, L Gao - International journal of biological sciences, 2018 - ncbi.nlm.nih.gov
Network-based computational method, with the emphasis on biomolecular interactions and
biological data integration, has succeeded in drug development and created new directions …
biological data integration, has succeeded in drug development and created new directions …
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice
MC Weng, MH Wang, JJ Tsai, YC Kuo, YC Liu… - Bioscience …, 2018 - portlandpress.com
Regorafenib has been demonstrated in our previous study to trigger apoptosis through
suppression of extracellular signal-regulated kinase (ERK)/nuclear factor-κB (NF-κB) …
suppression of extracellular signal-regulated kinase (ERK)/nuclear factor-κB (NF-κB) …
Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells
SY Chung, YH Chen, PR Lin, TC Chao, JC Su… - Cell death …, 2018 - nature.com
Signal transducer and activator of transcription 3 (STAT3) has been shown to play a critical
role in the maintenance of cancer stem cells (CSCs). Hence, the inhibition of STAT3 …
role in the maintenance of cancer stem cells (CSCs). Hence, the inhibition of STAT3 …
Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
JC Su, CH Chang, SH Wu, CW Shiau - Journal of Enzyme …, 2018 - Taylor & Francis
The unregulated activation of STAT3 has been demonstrated to occur in many cancers and
enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors …
enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors …
[图书][B] Lessons from Protein Tyrosine Phosphatase-pest Interactome: Towards a Better Understanding of Pancreatic Cancer Progression
E Ayoub - 2018 - search.proquest.com
Protein tyrosine phosphatase-PEST (PTP-PEST, PTPN12) is a cytosolic ubiquitous protein,
which in addition to its PTP domains, contains five proline-rich motifs allowing its interaction …
which in addition to its PTP domains, contains five proline-rich motifs allowing its interaction …