While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …

The innate immune kinase TBK 1 initiates inflammatory responses to combat infectious
pathogens by driving production of type I interferons. TBK 1 also controls metabolic …

A high rate of disease relapse makes epithelial ovarian cancer (EOC) the leading cause of
death among all gynecologic malignancies. These relapses are often due to tumor …

Morbidity in advanced prostate cancer patients is largely associated with bone metastatic
events. The development of novel therapeutic strategies is imperative in order to effectively …

Current clinical anti-androgen therapies in advanced prostate cancer (PCa) are driving an
increased incidence of neuroendocrine prostate cancer (NEPC), a histological variant …

Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the
development of multidrug resistance (MDR), minimum residual disease (MRD), tumor …

Induced and activated as part of the innate immune response, the first line of defence
against bacterial or viral infections, Inhibitor of Kappa-B Kinase ε (IKKε) triggers NF-κB and …

Inflammation is now widely accepted to be an essential mediator of the balance between
cell growth, metabolism, and autophagy. A group of kinases belonging to the IB kinase (IKK) …

Background: There is significant variation in clinical outcome between patients diagnosed
with prostate cancer (CaP). Although useful, statistical nomograms and risk stratification …