During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Abstract Idelalisib (GS-1101, CAL-101, Zydelig®) is an orally bioavailable, small-molecule
inhibitor of the delta isoform (p110δ) of the enzyme phosphoinositide 3-kinase (PI3K). In …

Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK)
networks and represents a critical challenge for precision medicine. Here, we show that …

Background: Glucose-sensing neurons are located in several parts of the brain, but are
concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance of …

Background Lung adenocarcinoma is the most common subtype of Non small cell lung
cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression …

A deconstruction of previously reported phosphoinositide 3-kinase δ (PI3Kδ) inhibitors and
subsequent regrowth led to the identification of a privileged fragment for PI3Kδ, which was …

PI3Kδ, which is mainly expressed in leukocytes, plays a critical role in B-cell receptor
mediated signaling pathway and has been extensively studied as a drug discovery target for …

Mast cells (MCs) play a crucial role in the pathogenesis of allergic diseases due to their
hypersensitive reaction to non-harmful substances that elicit an allergic response. As such …

ABSTRACT PI3Kδ, which is mainly expressed in leukocytes, plays a critical role in B-cell
receptor mediated signaling pathway and has been extensively studied as a drug discovery …