Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …

Alzheimer disease (AD) drug development has a high failure rate. Drug development
decision making can be improved based on lessons learned from past trials. Improved …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

Alzheimer's disease (AD) remains an incurable disease and lacks efficient diagnostic
methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it …