Research in the last two decades has identified many synaptic organizers in the central
nervous system that directly regulate the assembly of pre-and/or postsynaptic molecules …

Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the
morphogenesis and body patterning during the development of metazoan species. In recent …

Since its discovery, Wnt signaling has been shown to be one of the most crucial
morphogens in development and during the maturation of central nervous system. Its action …

Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of
amyloid‐β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory …

Secreted Wnts play crucial roles in synaptogenesis and synapse maintenance, but
endogenous factors promoting synapse elimination in central neurons remain unknown …

Several methods have been used to study the neuropathogenesis of Down syndrome (DS),
such as mouse aneuploidies, post mortem human brains, and in vitro cell culture of neural …

Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the
neocortex of the brain. This phenomenon precedes tau pathology, plaque formation, and …

The Wnt signaling pathway has been recognized as an important pathway, extending its
function throughout the lifespan. Evidence suggests that dysfunctional Wnt signaling in the …

Dendritic spines, a special kind of structure in nerve cells, play a key role in performing
cellular function. Structural abnormalities of the dendritic spine may contribute to synaptic …

The Ror‐family of receptor tyrosine kinases (RTKs) are involved critically in tissue genesis
and organogenesis during development. In mammals, Ror1 and Ror2, members of the Ror …