Diabetes has become a major burden of healthcare expenditure. Diabetes management
following a uniform treatment algorithm is often associated with progressive treatment failure …

Candidate gene, genome-wide association, exome array and sequencing studies have
identified more than 140 loci associated with type 2 diabetes (T2D) susceptibility. In this …

NAFLD is a polygenic condition but the individual and cumulative contribution of identified
genes remains to be established. To get additional insight into the genetic architecture of …

Abstract Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro-and
macrovascular complications that increase the morbidity and mortality of patients. The risk of …

Machine learning is increasingly used to inform consequential decisions. Yet, these
predictive models have been found to exhibit unexpected defects when trained on real …

Genome-wide association studies depend on accurate ascertainment of patient phenotype.
However, phenotyping is difficult, and it is often treated as an afterthought in these studies …

The protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ)
Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained subcutaneous …

Objective A strong genetic predisposition for type 2 diabetes mellitus (T2DM) may aggravate
the negative effects of low socioeconomic position (SEP) in the etiology of the disorder. This …

Predictive analytics is increasingly used to guide decision-making in many applications.
However, in practice, we often have limited data on the true predictive task of interest, and …

Background Published genetic risk scores for breast cancer (BC) so far have been based on
a relatively small number of markers and are not necessarily using the full potential of large …