Genetics of multiple sclerosis: an overview and new directions

NA Patsopoulos - Cold Spring Harbor …, 2018 - perspectivesinmedicine.cshlp.org
The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Low-frequency and rare-coding variation contributes to multiple sclerosis risk

M Mitrovič, NA Patsopoulos, AH Beecham… - Cell, 2018 - cell.com
Multiple sclerosis is a complex neurological disease, with∼ 20% of risk heritability
attributable to common genetic variants, including> 230 identified by genome-wide …

Genetic and genomic testing for neurologic disease in clinical practice

BL Fogel - Handbook of clinical neurology, 2018 - Elsevier
The influence of genetics on neurologic disease is broad and it is becoming more common
that clinicians are presented with a patient whose disease is likely of genetic origin. In the …

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

T James, M Lindén, H Morikawa… - Human molecular …, 2018 - academic.oup.com
Despite advancements in genetic studies, it is difficult to understand and characterize the
functional relevance of disease-associated genetic variants, especially in the context of a …

Organic solvents and MS susceptibility: interaction with MS risk HLA genes

AK Hedström, O Hössjer, M Katsoulis, I Kockum… - Neurology, 2018 - AAN Enterprises
Objective We hypothesize that different sources of lung irritation may contribute to elicit an
immune reaction in the lungs and subsequently lead to multiple sclerosis (MS) in people …

Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015

S Eskandarieh, NS Allahabadi, M Sadeghi… - BMC neurology, 2018 - Springer
Background Tehran is the capital of Iran with an increasing multiple sclerosis (MS)
prevalence. A retrospective population-based study was conducted to evaluate the trends of …

Investigation of ERG Gene Expression in Iranian Patients with Multiple Sclerosis

N Yazdanpanahi, M Etemadifar, MT Kardi… - Immunological …, 2018 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a common neuro-inflammatory disease arising from
interplay of multiple genetic and nongenetic factors. The complex etiology of MS highlights …

Стандартизованные регистры пациентов с рассеянным склерозом-важный инструмент при переходе на ценностно-ориентированное здравоохранение

ДА Андреев, НВ Хачанова, КА Кокушкин… - Проблемы …, 2018 - cyberleninka.ru
Цель исследования. Провести поиск и анализ литературных данных о принципах
формирования и применения регистров больных с рассеянным склерозом (РС) в …

[图书][B] Genetic Landscape of Multiple Sclerosis Susceptibility by Leveraging Multi-Omics Data

T James - 2018 - search.proquest.com
The main objective of the research studies presented in this thesis is to study the genetic
variants and the expression of genes that relate to Multiple Sclerosis (MS). MS is a polygenic …

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

NY Souren, LA Gerdes, P Lutsik, G Gasparoni… - bioRxiv, 2018 - biorxiv.org
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins that strongly argues for …